Running Head: Dual Outcomes of Chronic Nod2 Stimulation
نویسندگان
چکیده
1 2 The NLRP1 and NLRP3 Inflammasome is Essential for Distinct Outcomes of Decreased 3 Cytokines but Enhanced Bacterial Killing Upon Chronic Nod2 Stimulation 4 Matija Hedl and Clara Abraham 5 Department of Internal Medicine 6 Yale University 7 New Haven, CT 06510 8 Corresponding Author: 9 10 Clara Abraham, MD 11 Department of Internal Medicine 12 Section of Digestive Diseases 13 333 Cedar Street (LMP 1080) 14 New Haven, CT 06520 15 E-mail: [email protected] 16 17 Author contributions: M.H. and C.A. designed the experiments, analyzed the data and wrote the 18 manuscript. M.H. performed the experiments. C.A. obtained the funding. 19 20
منابع مشابه
NLRP1 and NLRP3 inflammasomes are essential for distinct outcomes of decreased cytokines but enhanced bacterial killing upon chronic Nod2 stimulation.
Upon chronic microbial exposure and pattern-recognition receptor (PRR) stimulation, myeloid-derived cells undergo a distinct transcriptional program relative to acute PRR stimulation, with proinflammatory pathways being downregulated. However, other host-response pathways might be differentially regulated, and this concept has been relatively unexplored. Understanding mechanisms regulating chro...
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